Hif sumo
Web18 de abr. de 2024 · Some are able to directly activate TRPV1, e.g., protons, or modulate the channel gating, e.g., prostaglandins and bradykinin 12,49,51, while others can … Web2 de nov. de 2007 · SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases ... RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol. Cell, 25 (2007), pp. 207-217.
Hif sumo
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Web5 de abr. de 2001 · Figure 1 Regulation of the interaction between pVHL and HIF-α subunits by oxygen and iron availability. (A) In vivo coimmunoprecipitation assay.RCC4 cells, which lack pVHL (lane 1), and a stable transfectant expressing HA-tagged pVHL (RCC4/VHL.HA, lanes 2 to 4) were labeled in the presence of the proteasomal inhibitor MG132, either in … Web13 de jan. de 2014 · Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells …
Web26 de jun. de 2024 · The loss of the Ulp2 SUMO protease, ... Shao R. et al. Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. Web8 de jan. de 2016 · Abstract. SUMOylation is a ubiquitin-related transient posttranslational modification pathway catalyzing the conjugation of small ubiquitin-like modifier (SUMO) …
WebHypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid … Web31 de jul. de 2014 · The ubiquitin-like SUMO (small ubiquitin-related modifier) system is a post-translational protein modification pathway in eukaryotes [ [ 1 ], [ 2 ]]. SUMOylation is a highly dynamic process, where deconjugation (deSUMOylation) is catalyzed by a family of cysteine proteases, termed SUMO-specific proteases or SUMO isopeptidases.
Web26 de abr. de 2024 · The levels of protein SUMOylation, hypoxia‑inducible factor (HIF)‑1α and vascular endothelial growth factor (VEGF) were determined by western blot analysis. …
WebHIF-1α was first immunoprecipitated ... Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still … birch grove golf club score cardWeb17 de dez. de 2024 · Furthermore, protein inhibitor of activated STAT 4 (PIAS4) was determined as the SUMO E3 ligase showing increased interaction with KDM5B under hypoxia condition. Inhibition of KDM5B caused significant downregulation of hypoxia-inducible factor-1α (HIF-1α) protein and target genes under hypoxia. birch grove health center la clinicaWeb16 de nov. de 2024 · SUMOylation in the hypoxia pathway. SUMOylation plays a positive role in maintaining the stabilization of hypoxia-inducible factor 1-alpha (HIF-1α).SUMO … dallas diescher facebookWebIn addition, the present data suggest that SUMO‑1 regulated HIF‑1α in response to hypoxia (gene silencing and overexpression). Finally, the co‑immunoprecipitation assays suggest … dallas diamond and gold exchangeWeb10 de out. de 2024 · SENP1 interacts with and deSUMOylates c-Myc in cells and in vitro. Overexpression of wild-type SENP1, but not its catalytically inactive C603S mutant, markedly stabilizes c-Myc and increases its levels and activity. Knockdown of SENP1 reduces c-Myc levels, induces cell cycle arrest, and drastically suppresses cell proliferation. dallas dfw airport terminal mapWeb30 de out. de 2024 · Post-translational modification by SUMO (small ubiquitin-like modifier) proteins has been shown to regulate a variety of functions of proteins, including protein … birch grove haywards heathWeb18 de abr. de 2024 · Some are able to directly activate TRPV1, e.g., protons, or modulate the channel gating, e.g., prostaglandins and bradykinin 12,49,51, while others can increase the translocation of pre-existing ... dallas diamonds women\u0027s football