WebNov 7, 2011 · Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with phosphocholine PDB DOI: 10.2210/pdb3UJ9/pdb Classification: TRANSFERASE Organism (s): Plasmodium falciparum Expression System: Escherichia coli Mutation (s): No Deposited: 2011-11-07 Released: 2011-11-30 WebAbstract. The human choline/ethanolamine phosphotransferase 1 (CEPT1) gene codes for a dual-specificity enzyme that catalyzes the de novo synthesis of the two major …
Evaluation of Antimalarial Activity of Ethanolic Extract of
WebPhosphocholine (pCho) is a precursor for phosphatidylcholine and osmoprotectants in plants. In plants, de novo synthesis of pCho relies on the phosphobase methylation … WebJan 1, 1998 · PhosphoBase is a database of experimentally verified phosphorylation sites. Version 1.0 contains 156 entries and 398 experimentally determined phosphorylation … devonshire close sawtry
Structural and biochemical analysis of phosphoethanolamine ...
WebIn this pathway, a pair of phosphoethanolamine methyltransferases (PMT) catalyze the sequential methylation of phosphoethanolamine to phosphocholine, which can be incorporated into phosphatidylcholine. RNAi experiments demonstrate that both PMT are required for normal growth and development of C. elegans. WebAll of the residues forming the phosphobase site are invariant between PfPMT, CePMT2, HcPMT2, and the second domain of AtPMT (FIGURE 3, FIGURE 4 and supplemental Fig. S3). Site-directed mutagenesis of amino acids in the phosphobase site also highlights the functional importance of interactions with the substrate phosphate group for activity . Weba phosphobase methylation route as well as a phosphatidylbase route, but the first methylation appears not to be restricted to the phosphobase level (9, 10). The initial methylation of P-EA in plants is catalyzed by S-adenosyl-L-methionine:phosphoethanolamine N-methyl-transferase (PEAMT), which has been detected in all species tested (1, 4, 11). devonshire close stevenage